Based in Urbana, Illinois, The Carle Foundation is the not-for-profit parent company of an integrated system of hospitals, clinics, a 400-member physician group, and health plan.

Carle is consistently recognized for providing quality care to a population of 1.3 million people. The 393-bed Carle Foundation Hospital houses the region's only Level I Trauma Center with Primary Stroke Center Designation and offers Level III perinatal services. Carle is ranked as a Best Hospital by U.S. News and World Report and by HealthGrades as one of America’s 100 Best Hospitals™, The hospital is among the top nationally for critical care, stroke, pulmonary and gastrointestinal care, having achieved Magnet® nursing status and Health Care’s Most Wired™ awards.

Health Alliance Medical Plans is a leading provider-sponsored plan, with J.D. Power ranking it "Highest in Member Satisfaction Among Commercial Health Plans in the Illinois/Indiana Region" in 2014. Carle serves people through high quality care, medical research, and education.

The University of Illinois at Urbana-Champaign and The Carle Foundation have a long history of cooperation. Now, encouraged and facilitated through IHSI, the partnership will foster more medical discoveries, improve student educational opportunities, enhance access to clinical and translational research trials for patients, encourage the recruitment of specialty physicians to Illinois, and provide an environment that supports collaboration.